|Other Names||Lipoprotein lipase, LPL, LPL, LIPD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL) (PubMed:27578112). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity)|
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LPL encodes lipoprotein lipase, which is expressed inheart, muscle, and adipose tissue. LPL functions as a homodimer,and has the dual functions of triglyceride hydrolase andligand/bridging factor for receptor-mediated lipoprotein uptake.Severe mutations that cause LPL deficiency result in type Ihyperlipoproteinemia, while less extreme mutations in LPL arelinked to many disorders of lipoprotein metabolism. [provided byRefSeq].
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Johansen, C.T., et al. Nat. Genet. 42(8):684-687(2010)Zabaneh, D., et al. PLoS ONE 5 (8) (2010) :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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