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PPL Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O60437
Clone Names 80703038
Peptide ID 80703038
Additional Information
Gene ID 5493
Other Names Periplakin, 190 kDa paraneoplastic pemphigus antigen, 195 kDa cornified envelope precursor protein, PPL, KIAA0568
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPL
Synonyms KIAA0568
Function Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.
Cellular Location Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane. Nucleus. Mitochondrion. Note=Associated with desmosomes and intermediate filaments
Tissue Location Expressed in stratified squamous epithelia and in some other epithelia.
Research Areas
Citations (0)

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The protein encoded by this gene is a component ofdesmosomes and of the epidermal cornified envelope inkeratinocytes. The N-terminal domain of this protein interacts withthe plasma membrane and its C-terminus interacts with intermediatefilaments. Through its rod domain, this protein forms complexeswith envoplakin. This protein may serve as a link between thecornified envelope and desmosomes as well as intermediatefilaments. AKT1/PKB, a protein kinase mediating a variety of cellgrowth and survival signaling processes, is reported to interactwith this protein, suggesting a possible role for this protein as alocalization signal in AKT1-mediated signaling. [provided byRefSeq].


Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Pyle, A.L., et al. Cardiovasc. Pathol. 19 (2), E13-E20 (2010) :Huang, Y., et al. Arch. Dermatol. Res. 301(10):703-709(2009)Boczonadi, V., et al. Exp. Cell Res. 313(16):3579-3591(2007)

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$ 80.00
Cat# BP14171b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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