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PRSS8 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q16651 |
|---|---|
| Clone Names | 100507010 |
| Gene ID | 5652 |
|---|---|
| Other Names | Prostasin, 3421-, Channel-activating protease 1, CAP1, Serine protease 8, Prostasin light chain, Prostasin heavy chain, PRSS8 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PRSS8 |
|---|---|
| Function | Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). |
| Cellular Location | [Prostasin]: Cell membrane; Single-pass membrane protein [Prostasin heavy chain]: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus |
| Tissue Location | Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a trypsinogen, which is a member of thetrypsin family of serine proteases. This enzyme is highly expressedin prostate epithelia and is one of several proteolytic enzymesfound in seminal fluid. The proprotein is cleaved to produce alight chain and a heavy chain which are associated by a disulfidebond. It is active on peptide linkages involving the carboxyl groupof lysine or arginine.
References
Chen, Y.W., et al. J. Biol. Chem. 285(41):31755-31762(2010)Chen, M., et al. Mol. Cell. Biochem. 337 (1-2), 259-266 (2010) :Fu, Y.Y., et al. Hum. Reprod. 25(3):623-632(2010)Ko, T., et al. J. Biomed. Biotechnol. 2010, 793843 (2010) :Chang, J.H., et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 31(6):712-719(2009)
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