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MCPH1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NEM0 |
|---|---|
| Clone Names | 100507323 |
| Gene ID | 79648 |
|---|---|
| Other Names | Microcephalin, MCPH1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MCPH1 (HGNC:6954) |
|---|---|
| Function | Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| Tissue Location | Expressed in fetal brain, liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a DNA damage response protein. Theencoded protein may play a role in G2/M checkpoint arrest viamaintenance of inhibitory phosphorylation of cyclin-dependentkinase 1. Mutations in this gene have been associated with primaryautosomal recessive microcephaly 1 and premature chromosomecondensation syndrome. Alternatively spliced transcript variantshave been described.
References
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Wang, Y.Q., et al. Hum. Mol. Genet. 13(11):1131-1137(2004)
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