|Other Names||C-C motif chemokine 15, Chemokine CC-2, HCC-2, Leukotactin-1, LKN-1, MIP-1 delta, Macrophage inflammatory protein 5, MIP-5, Mrp-2b, NCC-3, Small-inducible cytokine A15, CCL15(22-92), CCL15(25-92), CCL15(29-92), CCL15, MIP5, NCC3, SCYA15|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||MIP5, NCC3, SCYA15|
|Function||Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.|
|Tissue Location||Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients|
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This gene, chemokine (C-C motif) ligand 15, is one ofseveral CC cytokine genes clustered on 17q11.2. The CC cytokinesare secreted proteins characterized by two adjacent cysteines. Thecytokine encoded by this gene is chemotactic for T cells andmonocytes and induces N-acetyl-beta-D-glucosaminidase release inmonocytes. It induces changes in intracellular calciumconcentration in monocytes and is thought to act through the CCR1receptor. Read-through transcripts are expressed that include exonsfrom the downstream cytokine gene, chemokine (C-C motif) ligand 14,and are represented as GeneID: 348249.
Kitamura, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(29):13063-13068(2010)Cho, J.E., et al. Mol. Cells 29(1):35-39(2010)Kwon, S.H., et al. Nutr Res Pract 2(2):134-137(2008)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Escher, S.E., et al. J. Pept. Res. 63(1):36-47(2004)
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