|Other Names||Modulator of apoptosis 1, MAP-1, MAP1, Paraneoplastic antigen Ma4, MOAP1, PNMA4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.|
|Tissue Location||Widely expressed, with high levels in heart and brain.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene was identified by itsinteraction with apoptosis regulator BAX protein. This proteincontains a Bcl-2 homology 3 (BH3)-like motif, which is required forthe association with BAX. When overexpressed, this gene has beenshown to mediate caspase-dependent apoptosis.
Lee, S.S., et al. Exp. Cell Res. 315(7):1313-1325(2009)Foley, C.J., et al. Mol. Cell. Biol. 28(14):4520-4535(2008)Fu, N.Y., et al. Proc. Natl. Acad. Sci. U.S.A. 104(24):10051-10056(2007)Lim, J., et al. Cell 125(4):801-814(2006)Vos, M.D., et al. J. Biol. Chem. 281(8):4557-4563(2006)
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