|Other Names||Transmembrane channel-like protein 8, Epidermodysplasia verruciformis protein 2, TMC8, EVER2, EVIN2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable ion channel.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in placenta, prostate and testis.|
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Epidermodysplasia verruciformis (EV) is an autosomalrecessive dermatosis characterized by abnormal susceptibility tohuman papillomaviruses (HPVs) and a high rate of progression tosquamous cell carcinoma on sun-exposed skin. EV is caused bymutations in either of two adjacent genes located on chromosome17q25.3. Both of these genes encode integral membrane proteins thatlocalize to the endoplasmic reticulum and are predicted to formtransmembrane channels. This gene encodes a transmembranechannel-like protein with 8 predicted transmembrane domains and 3leucine zipper motifs.
McDermott, D.F., et al. Pediatr Dermatol 26(3):306-310(2009)Patel, A.S., et al. Int. J. Cancer 122(10):2377-2379(2008)Zavattaro, E., et al. J. Invest. Dermatol. 128(3):732-735(2008)Lazarczyk, M., et al. J. Exp. Med. 205(1):35-42(2008)Rady, P.L., et al. Br. J. Dermatol. 157(4):831-833(2007)
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