|Other Names||Potassium channel subfamily K member 10, Outward rectifying potassium channel protein TREK-2, TREK-2 K(+) channel subunit, KCNK10, TREK2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain|
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The protein encoded by this gene belongs to the family ofpotassium channel proteins containing two pore-forming P domains.This channel is an open rectifier which primarily passes outwardcurrent under physiological K+ concentrations, and is stimulatedstrongly by arachidonic acid and to a lesser degree by membranestretching, intracellular acidification, and general anaesthetics.Several alternatively spliced transcript variants encodingdifferent isoforms have been identified for this gene. [provided byRefSeq].
Gierten, J., et al. Br. J. Pharmacol. 154(8):1680-1690(2008)Huang, D., et al. Med. Hypotheses 70(3):618-624(2008)Goldstein, S.A., et al. Pharmacol. Rev. 57(4):527-540(2005)Gu, W., et al. J. Physiol. (Lond.) 539 (PT 3), 657-668 (2002) :Goldstein, S.A., et al. Nat. Rev. Neurosci. 2(3):175-184(2001)
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