|Other Names||Potassium channel subfamily K member 10, Outward rectifying potassium channel protein TREK-2, TREK-2 K(+) channel subunit, KCNK10, TREK2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain|
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the family ofpotassium channel proteins containing two pore-forming P domains.This channel is an open rectifier which primarily passes outwardcurrent under physiological K+ concentrations, and is stimulatedstrongly by arachidonic acid and to a lesser degree by membranestretching, intracellular acidification, and general anaesthetics.Several alternatively spliced transcript variants encodingdifferent isoforms have been identified for this gene. [provided byRefSeq].
Gierten, J., et al. Br. J. Pharmacol. 154(8):1680-1690(2008)Huang, D., et al. Med. Hypotheses 70(3):618-624(2008)Goldstein, S.A., et al. Pharmacol. Rev. 57(4):527-540(2005)Gu, W., et al. J. Physiol. (Lond.) 539 (PT 3), 657-668 (2002) :Goldstein, S.A., et al. Nat. Rev. Neurosci. 2(3):175-184(2001)
If you have any additional inquiries please email technical services at email@example.com.