KCNK10 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P57789 |
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Clone Names | 100517215 |
Gene ID | 54207 |
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Other Names | Potassium channel subfamily K member 10, Outward rectifying potassium channel protein TREK-2, TREK-2 K(+) channel subunit, KCNK10, TREK2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | KCNK10 |
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Synonyms | TREK2 |
Function | Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. |
Cellular Location | Membrane; Multi-pass membrane protein |
Tissue Location | Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the family ofpotassium channel proteins containing two pore-forming P domains.This channel is an open rectifier which primarily passes outwardcurrent under physiological K+ concentrations, and is stimulatedstrongly by arachidonic acid and to a lesser degree by membranestretching, intracellular acidification, and general anaesthetics.Several alternatively spliced transcript variants encodingdifferent isoforms have been identified for this gene. [provided byRefSeq].
References
Gierten, J., et al. Br. J. Pharmacol. 154(8):1680-1690(2008)Huang, D., et al. Med. Hypotheses 70(3):618-624(2008)Goldstein, S.A., et al. Pharmacol. Rev. 57(4):527-540(2005)Gu, W., et al. J. Physiol. (Lond.) 539 (PT 3), 657-668 (2002) :Goldstein, S.A., et al. Nat. Rev. Neurosci. 2(3):175-184(2001)
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