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Mouse Mapk7 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9WVS8
Clone Names 110316253
Peptide ID 110316253
Additional Information
Gene ID 23939
Other Names Mitogen-activated protein kinase 7, MAP kinase 7, MAPK 7, Big MAP kinase 1, BMK-1, Extracellular signal-regulated kinase 5, ERK-5, Mapk7, Bmk1, Erk5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mapk7
Synonyms Bmk1, Erk5
Function Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity).
Cellular Location Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation Isoform 2: Nucleus. Note=Isoform 2 is detected only in the nucleus. Translocates to the nucleus upon activation (By similarity).
Tissue Location Detected in testis, brain, kidney, lung and heart. Detected in total embryo (at protein level)
Research Areas
Citations (0)

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Background

Mapk7 plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways (By similarity).

References

Garcia-Hoz, C., et al. J. Biol. Chem. 285(18):13480-13489(2010)Biyashev, D., et al. J. Biol. Chem. 285(18):13517-13524(2010)Kimura, T.E., et al. Circ. Res. 106(5):961-970(2010)Carter, E.J., et al. J. Cell. Sci. 122 (PT 17), 3104-3112 (2009) :Clape, C., et al. PLoS ONE 4 (10), E7542 (2009) :

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$ 80.00
Cat# BP14267a
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