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Mouse Matk Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P41242 |
|---|---|
| Clone Names | 110316266 |
| Gene ID | 17179 |
|---|---|
| Other Names | Megakaryocyte-associated tyrosine-protein kinase, Protein kinase NTK, Tyrosine-protein kinase CTK, Matk, Ctk, Ntk |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Matk |
|---|---|
| Synonyms | Ctk, Ntk |
| Function | Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC- family members in brain by specifically phosphorylating their C- terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T- cell proliferation. |
| Cellular Location | Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation. |
| Tissue Location | Most abundant in brain, and to a lesser extent in the spleen, the thymus and the liver. Also found in the T-cell lineage |
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Provided below are standard protocols that you may find useful for product applications.
Background
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
References
Lee, B.C., et al. Blood 108(3):904-907(2006)Robinson, D.R., et al. Oncogene 19(49):5548-5557(2000)Puttagunta, R., et al. Genome Res. 10(9):1369-1380(2000)Samokhvalov, I., et al. Biochem. Mol. Biol. Int. 43(1):115-122(1997)Kozak, C.A., et al. Mamm. Genome 7(2):164-165(1996)
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