|Other Names||Desmin, DES|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction.|
|Cellular Location||Cytoplasm, myofibril, sarcomere, Z line Cytoplasm. Cell membrane, sarcolemma. Note=Localizes in the intercalated disks which occur at the Z line of cardiomyocytes (PubMed:24200904, PubMed:26724190).|
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This gene encodes a muscle-specific class III intermediatefilament. Homopolymers of this protein form a stableintracytoplasmic filamentous network connecting myofibrils to eachother and to the plasma membrane. Mutations in this gene areassociated with desmin-related myopathy, a familial cardiac andskeletal myopathy (CSM), and with distal myopathies. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)van Spaendonck-Zwarts, K., et al. Clin. Genet. (2010) In press :Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)Bar, H., et al. J. Mol. Biol. 397(5):1188-1198(2010)Levin, J., et al. J. Neuropathol. Exp. Neurol. 69(4):415-424(2010)
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