|Other Names||Transcriptional enhancer factor TEF-5, DTEF-1, TEA domain family member 3, TEAD-3, TEAD3, TEAD5, TEF5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.|
|Tissue Location||Preferentially expressed in the placenta.|
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This gene product is a member of the transcriptionalenhancer factor (TEF) family of transcription factors, whichcontain the TEA/ATTS DNA-binding domain. It is predominantlyexpressed in the placenta and is involved in the transactivation ofthe chorionic somatomammotropin-B gene enhancer. Translation ofthis protein is initiated at a non-AUG (AUA) start codon. [providedby RefSeq].
Zhang, H., et al. J. Biol. Chem. 284(20):13355-13362(2009)Zhao, B., et al. Genes Dev. 22(14):1962-1971(2008)Peng, L., et al. Mol. Endocrinol. 18(8):2049-2060(2004)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Maeda, T., et al. J. Biol. Chem. 277(27):24346-24352(2002)
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