|Other Names||Stanniocalcin-2, STC-2, Stanniocalcin-related protein, STC-related protein, STCRP, STC2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has an anti-hypocalcemic action on calcium and phosphate homeostasis.|
|Tissue Location||Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes|
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This gene encodes a secreted, homodimeric glycoproteinthat is expressed in a wide variety of tissues and may haveautocrine or paracrine functions. The encoded protein has 10 of its15 cysteine residues conserved among stanniocalcin family membersand is phosphorylated by casein kinase 2 exclusively on its serineresidues. Its C-terminus contains a cluster of histidine residueswhich may interact with metal ions. The protein may play a role inthe regulation of renal and intestinal calcium and phosphatetransport, cell metabolism, or cellular calcium/phosphatehomeostasis. Constitutive overexpression of human stanniocalcin 2in mice resulted in pre- and postnatal growth restriction, reducedbone and skeletal muscle growth, and organomegaly. Expression ofthis gene is induced by estrogen and altered in some breastcancers.
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Law, A.Y., et al. Exp. Cell Res. 316(3):466-476(2010)Volland, S., et al. Int. J. Cancer 125(9):2049-2057(2009)Ieta, K., et al. Int. J. Cancer 125(4):926-931(2009)Tamura, K., et al. Cancer Sci. 100(5):914-919(2009)
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