|Other Names||Inhibitor of growth protein 1, ING1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.|
|Tissue Location||Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines|
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This gene encodes a tumor suppressor protein that caninduce cell growth arrest and apoptosis. The encoded protein is anuclear protein that physically interacts with the tumor suppressorprotein TP53 and is a component of the p53 signaling pathway.Reduced expression and rearrangement of this gene have beendetected in various cancers. Multiple alternatively splicedtranscript variants encoding distinct isoforms have been reported.
Zhu, Z., et al. Hepatology 49(2):504-512(2009)Sayan, B., et al. Hybridoma (Larchmt) (2009) In press :Tallen, G., et al. Oncol. Res. 18 (2-3), 95-105 (2009) :Halaschek-Wiener, J., et al. PLoS ONE 4 (8), E6641 (2009) :Han, X., et al. Nat. Cell Biol. 10(11):1333-1340(2008)
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