|Other Names||Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, BIN1, AMPHL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.|
|Cellular Location||Isoform BIN1: Nucleus.|
|Tissue Location||Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier Isoform BIN1 is widely expressed with highest expression in skeletal muscle.|
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This gene encodes several isoforms of a nucleocytoplasmicadaptor protein, one of which was initially identified as aMYC-interacting protein with features of a tumor suppressor.Isoforms that are expressed in the central nervous system may beinvolved in synaptic vesicle endocytosis and may interact withdynanim, synaptojanin, endophilin, and clathrin. Isoforms that areexpressed in muscle and ubiquitously expressed isoforms localize tothe cytoplasm and nucleus and activate a caspase-independentapoptotic process. Studies in mouse suggest that this gene plays animportant role in cardiac muscle development. Alternate splicing ofthe gene results in ten transcript variants encoding differentisoforms. Aberrant splice variants expressed in tumor cell lineshave also been described.
Biffi, A., et al. Arch. Neurol. 67(6):677-685(2010)Seshadri, S., et al. JAMA 303(18):1832-1840(2010)Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Claeys, K.G., et al. Neurology 74(6):519-521(2010)Hong, T.T., et al. PLoS Biol. 8 (2), E1000312 (2010) :
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