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XRN2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9H0D6
Clone Names 100507022
Peptide ID 100507022
Additional Information
Gene ID 22803
Other Names 5'-3' exoribonuclease 2, 3113-, DHM1-like protein, DHP protein, XRN2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name XRN2
Function Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).
Cellular Location Nucleus, nucleolus
Tissue Location Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.
Research Areas
Citations (0)

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This gene shares similarity with the mouse Dhm1 and theyeast dhp1 gene. The yeast gene is involved in homologousrecombination and RNA metabolism, such as RNA synthesis and RNAtrafficking. Complementation studies show that Dhm1 has a similarfunction in mouse as dhp1. The function of the human gene has notyet been determined. Transcript variants encoding differentisoforms have been noted for this gene; however, their full-lengthnature is not known.


Lu, Y., et al. Oncogene 29(7):1041-1049(2010)Yang, X.C., et al. Mol. Cell. Biol. 29(1):31-42(2009)Kaneko, S., et al. Genes Dev. 21(14):1779-1789(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 80.00
Cat# BP14359a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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