|Other Names||5'-3' exoribonuclease 2, 3113-, DHM1-like protein, DHP protein, XRN2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).|
|Cellular Location||Nucleus, nucleolus|
|Tissue Location||Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
This gene shares similarity with the mouse Dhm1 and theyeast dhp1 gene. The yeast gene is involved in homologousrecombination and RNA metabolism, such as RNA synthesis and RNAtrafficking. Complementation studies show that Dhm1 has a similarfunction in mouse as dhp1. The function of the human gene has notyet been determined. Transcript variants encoding differentisoforms have been noted for this gene; however, their full-lengthnature is not known.
Lu, Y., et al. Oncogene 29(7):1041-1049(2010)Yang, X.C., et al. Mol. Cell. Biol. 29(1):31-42(2009)Kaneko, S., et al. Genes Dev. 21(14):1779-1789(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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