|Other Names||Tachykinin-3, ZNEUROK1, Neurokinin-B, NKB, Neuromedin-K, TAC3, NKNB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function.|
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This gene encodes a member of the tachykinin family ofsecreted neuropeptides. The encoded protein is primarily expressedin the central and peripheral nervous system and functions as aneurotransmitter. This protein is the ligand for the neurokinin-3receptor. This protein is also expressed in the outersyncytiotrophoblast of the placenta and may be associated withpregnancy-induced hypertension and pre-eclampsia. Mutations in thisgene are associated with normosmic hypogonadotropic hypogonadism.Alternate splicing results in multiple transcript variants.
Klassert, T.E., et al. J. Neuroimmunol. 227 (1-2), 202-207 (2010) :Hrabovszky, E., et al. Eur. J. Neurosci. 31(11):1984-1998(2010)Gianetti, E., et al. J. Clin. Endocrinol. Metab. 95(6):2857-2867(2010)Young, J., et al. J. Clin. Endocrinol. Metab. 95(5):2287-2295(2010)Semple, R.K., et al. Front Horm Res 39, 133-141 (2010) :
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