|Other Names||Homeobox protein Hox-C4, Homeobox protein CP19, Homeobox protein Hox-3E, HOXC4, HOX3E|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.|
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This gene belongs to the homeobox family of genes. Thehomeobox genes encode a highly conserved family of transcriptionfactors that play an important role in morphogenesis in allmulticellular organisms. Mammals possess four similar homeobox geneclusters, HOXA, HOXB, HOXC and HOXD, which are located on differentchromosomes and consist of 9 to 11 genes arranged in tandem. Thisgene, HOXC4, is one of several homeobox HOXC genes located in acluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6,share a 5' non-coding exon. Transcripts may include the shared exonspliced to the gene-specific exons, or they may include only thegene-specific exons. Two alternatively spliced variants that encodethe same protein have been described for HOXC4. Transcript variantone includes the shared exon, and transcript variant two includesonly gene-specific exons.
Park, S.R., et al. Nat. Immunol. 10(5):540-550(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Wissmuller, S., et al. Nucleic Acids Res. 34(6):1735-1744(2006)Gong, L.G., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22(5):497-501(2005)Kim, E.C., et al. J. Biol. Chem. 279(40):42258-42269(2004)
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