|Other Names||Eukaryotic translation initiation factor 4E transporter, 4E-T, eIF4E transporter, Eukaryotic translation initiation factor 4E nuclear import factor 1, EIF4ENIF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a nucleocytoplasmicshuttle protein for the translation initiation factor eIF4E. Thisshuttle protein interacts with the importin alpha-beta complex tomediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localizationsignal and nuclear export signals. Multiple transcript variantsencoding different isoforms have been found for this gene.
Suzuki, Y., et al. J. Biol. Chem. 284(51):35597-35604(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Lee, H.C., et al. Biochem. Biophys. Res. Commun. 369(4):1160-1165(2008)Denoeud, F., et al. Genome Res. 17(6):746-759(2007)Lim, J., et al. Cell 125(4):801-814(2006)
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