|Other Names||Male-specific lethal 1 homolog, MSL-1, Male-specific lethal 1-like 1, MSL1-like 1, Male-specific lethal-1 homolog 1, MSL1, MSL1L1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.|
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Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure.
Gironella, M., et al. J. Cell. Physiol. 221(3):594-602(2009)Mendjan, S., et al. Mol. Cell 21(6):811-823(2006)Smith, E.R., et al. Mol. Cell. Biol. 25(21):9175-9188(2005)Marin, I. J. Mol. Evol. 56(5):527-539(2003)
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