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MSL1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q68DK7
Clone Names 100517262
Peptide ID 100517262
Additional Information
Gene ID 339287
Other Names Male-specific lethal 1 homolog, MSL-1, Male-specific lethal 1-like 1, MSL1-like 1, Male-specific lethal-1 homolog 1, MSL1, MSL1L1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MSL1
Synonyms MSL1L1
Function Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure.

References

Gironella, M., et al. J. Cell. Physiol. 221(3):594-602(2009)Mendjan, S., et al. Mol. Cell 21(6):811-823(2006)Smith, E.R., et al. Mol. Cell. Biol. 25(21):9175-9188(2005)Marin, I. J. Mol. Evol. 56(5):527-539(2003)

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$ 80.00
Cat# BP14386c
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