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DUSP7 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q16829
Clone Names 100525009
Peptide ID 100525009
Additional Information
Gene ID 1849
Other Names Dual specificity protein phosphatase 7, Dual specificity protein phosphatase PYST2, DUSP7, PYST2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP7 (HGNC:3073)
Function Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity).
Cellular Location Cytoplasm.
Tissue Location Strongly expressed in liver (PubMed:8670865). Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells (PubMed:14576828).
Research Areas
Citations (0)

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Dual-specificity phosphatases (DUSPs) constitute a largeheterogeneous subgroup of the type I cysteine-basedprotein-tyrosine phosphatase superfamily. DUSPs are characterizedby their ability to dephosphorylate both tyrosine andserine/threonine residues. DUSP7 belongs to a class of DUSPs,designated MKPs, that dephosphorylate MAPK (mitogen-activatedprotein kinase) proteins ERK (see MIM 601795), JNK (see MIM601158), and p38 (see MIM 600289) with specificity distinct fromthat of individual MKP proteins. MKPs contain a highly conservedC-terminal catalytic domain and an N-terminal Cdc25 (see MIM116947)-like (CH2) domain. MAPK activation cascades mediate variousphysiologic processes, including cellular proliferation, apoptosis,differentiation, and stress responses (summary by Patterson et al.,2009 [PubMed 19228121]).


Patterson, K.I., et al. Biochem. J. 418(3):475-489(2009)Amit, I., et al. Nat. Genet. 39(4):503-512(2007)Orlev, L.N., et al. Immunol. Lett. 92 (1-2), 149-156 (2004) :Levy-Nissenbaum, O., et al. Genes Chromosomes Cancer 39(1):37-47(2004)Pasquali, C., et al. Mol. Endocrinol. 17(11):2228-2239(2003)

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$ 80.00
Cat# BP14393c
Availability: In Stock
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