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DUSP7 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q16829
Clone Names 100525009
Peptide ID 100525009
Additional Information
Gene ID 1849
Other Names Dual specificity protein phosphatase 7, Dual specificity protein phosphatase PYST2, DUSP7, PYST2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP7
Synonyms PYST2
Function Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.
Cellular Location Cytoplasm.
Tissue Location Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells.
Research Areas
Citations (0)

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Dual-specificity phosphatases (DUSPs) constitute a largeheterogeneous subgroup of the type I cysteine-basedprotein-tyrosine phosphatase superfamily. DUSPs are characterizedby their ability to dephosphorylate both tyrosine andserine/threonine residues. DUSP7 belongs to a class of DUSPs,designated MKPs, that dephosphorylate MAPK (mitogen-activatedprotein kinase) proteins ERK (see MIM 601795), JNK (see MIM601158), and p38 (see MIM 600289) with specificity distinct fromthat of individual MKP proteins. MKPs contain a highly conservedC-terminal catalytic domain and an N-terminal Cdc25 (see MIM116947)-like (CH2) domain. MAPK activation cascades mediate variousphysiologic processes, including cellular proliferation, apoptosis,differentiation, and stress responses (summary by Patterson et al.,2009 [PubMed 19228121]).


Patterson, K.I., et al. Biochem. J. 418(3):475-489(2009)Amit, I., et al. Nat. Genet. 39(4):503-512(2007)Orlev, L.N., et al. Immunol. Lett. 92 (1-2), 149-156 (2004) :Levy-Nissenbaum, O., et al. Genes Chromosomes Cancer 39(1):37-47(2004)Pasquali, C., et al. Mol. Endocrinol. 17(11):2228-2239(2003)

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$ 80.00
Cat# BP14393c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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