|Other Names||Dual specificity protein phosphatase 7, Dual specificity protein phosphatase PYST2, DUSP7, PYST2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.|
|Tissue Location||Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells.|
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Dual-specificity phosphatases (DUSPs) constitute a largeheterogeneous subgroup of the type I cysteine-basedprotein-tyrosine phosphatase superfamily. DUSPs are characterizedby their ability to dephosphorylate both tyrosine andserine/threonine residues. DUSP7 belongs to a class of DUSPs,designated MKPs, that dephosphorylate MAPK (mitogen-activatedprotein kinase) proteins ERK (see MIM 601795), JNK (see MIM601158), and p38 (see MIM 600289) with specificity distinct fromthat of individual MKP proteins. MKPs contain a highly conservedC-terminal catalytic domain and an N-terminal Cdc25 (see MIM116947)-like (CH2) domain. MAPK activation cascades mediate variousphysiologic processes, including cellular proliferation, apoptosis,differentiation, and stress responses (summary by Patterson et al.,2009 [PubMed 19228121]).
Patterson, K.I., et al. Biochem. J. 418(3):475-489(2009)Amit, I., et al. Nat. Genet. 39(4):503-512(2007)Orlev, L.N., et al. Immunol. Lett. 92 (1-2), 149-156 (2004) :Levy-Nissenbaum, O., et al. Genes Chromosomes Cancer 39(1):37-47(2004)Pasquali, C., et al. Mol. Endocrinol. 17(11):2228-2239(2003)
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