|Other Names||E3 ubiquitin-protein ligase RNF144A, 632-, RING finger protein 144A, UbcM4-interacting protein 4, Ubiquitin-conjugating enzyme 7-interacting protein 4, RNF144A, KIAA0161, RNF144, UBCE7IP4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0161, RNF144, UBCE7IP4|
|Function||E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.|
|Cellular Location||Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this protein contains a RINGfinger, a motif known to be involved in protein-DNA andprotein-protein interactions. The mouse counterpart of this proteinhas been shown to interact with Ube2l3/UbcM4, which is anubiquitin-conjugating enzyme involved in embryonic development.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Adkins, D.E., et al. Mol. Psychiatry (2010) In press :Hoja, M.R., et al. Exp. Cell Res. 259(1):239-246(2000)Martinez-Noel, G., et al. FEBS Lett. 454(3):257-261(1999)
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