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RNF144A Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P50876 |
|---|---|
| Clone Names | 100525030 |
| Gene ID | 9781 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase RNF144A, 632-, RING finger protein 144A, UbcM4-interacting protein 4, Ubiquitin-conjugating enzyme 7-interacting protein 4, RNF144A, KIAA0161, RNF144, UBCE7IP4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RNF144A |
|---|---|
| Synonyms | KIAA0161, RNF144, UBCE7IP4 |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:26216882). Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage (PubMed:24979766). Positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination and increasing its 'Lys-6'-linked ubiquitination and translocation from the endoplasmic reticulum to the Golgi leading to downstream signaling pathways (PubMed:37955227). Plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination (PubMed:30171075). Increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol (PubMed:33067254). |
| Cellular Location | Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane. Endosome membrane. Endoplasmic reticulum membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this protein contains a RINGfinger, a motif known to be involved in protein-DNA andprotein-protein interactions. The mouse counterpart of this proteinhas been shown to interact with Ube2l3/UbcM4, which is anubiquitin-conjugating enzyme involved in embryonic development.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Adkins, D.E., et al. Mol. Psychiatry (2010) In press :Hoja, M.R., et al. Exp. Cell Res. 259(1):239-246(2000)Martinez-Noel, G., et al. FEBS Lett. 454(3):257-261(1999)
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