|Other Names||Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5, SENP5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.|
|Cellular Location||Nucleus, nucleolus|
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Provided below are standard protocols that you may find useful for product applications.
The reversible posttranslational modification of proteinsby the addition of small ubiquitin-like SUMO proteins (see SUMO1;MIM 601912) is required for numerous biologic processes.SUMO-specific proteases, such as SENP5, are responsible for theinitial processing of SUMO precursors to generate a C-terminaldiglycine motif required for the conjugation reaction. They alsohave isopeptidase activity for the removal of SUMO from highmolecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed16738315]).
Yun, C., et al. J. Cell Biol. 183(4):589-595(2008)Ding, X., et al. Oncol. Rep. 20(5):1041-1045(2008)Gong, L., et al. J. Biol. Chem. 281(23):15869-15877(2006)Di Bacco, A., et al. Mol. Cell. Biol. 26(12):4489-4498(2006)Yeh, E.T., et al. Gene 248 (1-2), 1-14 (2000) :
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