|Other Names||Long-chain-fatty-acid--CoA ligase 4, Long-chain acyl-CoA synthetase 4, LACS 4, ACSL4, ACS4, FACL4, LACS4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ACS4, FACL4, LACS4|
|Function||Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.|
|Cellular Location||Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an isozyme of thelong-chain fatty-acid-coenzyme A ligase family. Although differingin substrate specificity, subcellular localization, and tissuedistribution, all isozymes of this family convert free long-chainfatty acids into fatty acyl-CoA esters, and thereby play a key rolein lipid biosynthesis and fatty acid degradation. This isozymepreferentially utilizes arachidonate as substrate. The absence ofthis enzyme may contribute to the mental retardation or Alportsyndrome. Alternative splicing of this gene generates 2 transcriptvariants.
Bosker, F.J., et al. Mol. Psychiatry (2010) In press :Zhang, Y., et al. Hum. Mol. Genet. 18(20):3894-3905(2009)Zeman, M., et al. Tohoku J. Exp. Med. 217(4):287-293(2009)An, C., et al. Neurosci. Lett. 441(2):197-200(2008)Hu, C., et al. Cancer Biol. Ther. 7(1):131-134(2008)
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