|Other Names||Serine hydroxymethyltransferase, cytosolic, SHMT, Glycine hydroxymethyltransferase, Serine methylase, SHMT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160).|
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This gene encodes the cellular form of serinehydroxymethyltransferase, a pyridoxal phosphate-containing enzymethat catalyzes the reversible conversion of serine andtetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate.This reaction provides one carbon units for synthesis ofmethionine, thymidylate, and purines in the cytoplasm. This gene islocated within the Smith-Magenis syndrome region on chromosome 17.Alternative splicing of this gene results in 2 transcript variantsencoding 2 different isoforms. Additional transcript variants havebeen described, but their biological validity has not beendetermined.
Porter, K.E., et al. Environ. Res. 110(6):580-587(2010)Summers, C.M., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(8):679-688(2010)Vijayakrishnan, J., et al. Haematologica 95(8):1405-1414(2010)Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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