|Other Names||Histamine N-methyltransferase, HMT, HNMT|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1442b was selected from the C-term region of human HNMT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.|
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Provided below are standard protocols that you may find useful for product applications.
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalianbrain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.
Aksoy, S., et al., Biochem. Biophys. Res. Commun. 219(2):548-554 (1996).
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