|Other Names||Desmoglein-1, Cadherin family member 4, Desmosomal glycoprotein 1, DG1, DGI, Pemphigus foliaceus antigen, DSG1, CDHF4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome|
|Tissue Location||Epidermis, tongue, tonsil and esophagus.|
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Provided below are standard protocols that you may find useful for product applications.
Desmosomes are cell-cell junctions between epithelial,myocardial and certain other cell types. Desmoglein 1 is acalcium-binding transmembrane glycoprotein component of desmosomesin vertebrate epithelial cells. Currently, three desmogleinsubfamily members have been identified and all are members of thecadherin cell adhesion molecule superfamily. These desmoglein genefamily members are located in a cluster on chromosome 18. Theprotein encoded by this gene has been identified as the autoantigenof the autoimmune skin blistering disease pemphigus foliaceus.
Rothenberg, M.E., et al. Nat. Genet. 42(4):289-291(2010)Naoe, Y., et al. J. Dermatol. Sci. 57(3):192-198(2010)Qian, Y., et al. J. Invest. Dermatol. 129(12):2823-2834(2009)Spindler, V., et al. J. Biol. Chem. 284(44):30556-30564(2009)Getsios, S., et al. J. Cell Biol. 185(7):1243-1258(2009)
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