|Other Names||Mitogen-activated protein kinase 4, MAP kinase 4, MAPK 4, Extracellular signal-regulated kinase 4, ERK-4, Mapk4, Erk4, Prkm4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5|
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Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle (By similarity).
Klinger, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(39):16710-16715(2009)Kesavan, C., et al. Bone 41(2):223-230(2007)Kant, S., et al. J. Biol. Chem. 281(46):35511-35519(2006)Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)Xu, H., et al. J. Biol. Chem. 278(32):30187-30192(2003)
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