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Mouse Mapk4 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6P5G0 |
|---|---|
| Clone Names | 110316251 |
| Gene ID | 225724 |
|---|---|
| Other Names | Mitogen-activated protein kinase 4, MAP kinase 4, MAPK 4, Extracellular signal-regulated kinase 4, ERK-4, Mapk4, Erk4, Prkm4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Mapk4 |
|---|---|
| Synonyms | Erk4, Prkm4 |
| Function | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. |
| Cellular Location | Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5 |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle (By similarity).
References
Klinger, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(39):16710-16715(2009)Kesavan, C., et al. Bone 41(2):223-230(2007)Kant, S., et al. J. Biol. Chem. 281(46):35511-35519(2006)Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)Xu, H., et al. J. Biol. Chem. 278(32):30187-30192(2003)
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