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Mouse Nek11 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8C0Q4 |
|---|---|
| Clone Names | 110316287 |
| Gene ID | 208583 |
|---|---|
| Other Names | Serine/threonine-protein kinase Nek11, Never in mitosis A-related kinase 11, NimA-related protein kinase 11, Nek11 {ECO:0000312|MGI:MGI:2442276} |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Nek11 {ECO:0000312|MGI:MGI:2442276} |
|---|---|
| Function | Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q8NG66}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8NG66}. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells {ECO:0000250|UniProtKB:Q8NG66} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Possible role in S-phase checkpoint mechanism (By similarity).
References
Katayama, S., et al. Science 309(5740):1564-1566(2005)
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