|Other Names||A-kinase anchor protein 4, AKAP-4, A-kinase anchor protein 82 kDa, AKAP 82, hAKAP82, Major sperm fibrous sheath protein, HI, Protein kinase A-anchoring protein 4, PRKA4, AKAP4 (HGNC:374), AKAP82|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Major structural component of sperm fibrous sheath. Plays a role in sperm motility.|
|Cellular Location||Cell projection, cilium, flagellum. Note=Localizes to the principle piece of the sperm flagellum|
|Tissue Location||Testis specific; only expressed in round spermatids.|
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Provided below are standard protocols that you may find useful for product applications.
The A-kinase anchor proteins (AKAPs) are a group ofstructurally diverse proteins, which have the common function ofbinding to the regulatory subunit of protein kinase A (PKA) andconfining the holoenzyme to discrete locations within the cell.This gene encodes a member of the AKAP family. The encoded proteinis localized to the sperm flagellum and may be involved in theregulation of sperm motility. Alternative splicing of this generesults in two transcript variants encoding different isoforms.
Moretti, E., et al. Asian J. Androl. 9(5):641-649(2007)Lefievre, L., et al. Proteomics 7(17):3066-3084(2007)Ross, M.T., et al. Nature 434(7031):325-337(2005)Brown, P.R., et al. Biol. Reprod. 68(6):2241-2248(2003)Ficarro, S., et al. J. Biol. Chem. 278(13):11579-11589(2003)
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