|Other Names||Serine/threonine-protein kinase 16, Embryo-derived protein kinase, Edpk, Myristoylated and palmitoylated serine/threonine-protein kinase, MPSK, Protein kinase Krct, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, Tyrosine-protein kinase STK16, Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||Edpk, Krct, Mpsk1, Pkl12, Tsf1|
|Function||Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates (By similarity). May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.|
|Cellular Location||Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Associates with Golgi and Golgi-derived vesicles|
|Tissue Location||Ubiquitously expressed at low levels. Relatively higher levels in testis, kidney and liver|
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Provided below are standard protocols that you may find useful for product applications.
Protein kinase that act on both serine and threonine residues.
Hoffman, B.G., et al. Genome Biol. 9 (6), R99 (2008) :Guinea, B., et al. Exp. Cell Res. 312(2):135-144(2006)Blackshaw, S., et al. PLoS Biol. 2 (9), E247 (2004) :Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)Ligos, J.M., et al. J. Biol. Chem. 277(8):6333-6343(2002)
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