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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Mouse Taok2 Antibody (Center) Blocking Peptide   

Mouse Taok2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q6ZQ29
Clone Names 110328116
Peptide ID 110328116
Additional Information
Gene ID 381921
Other Names Serine/threonine-protein kinase TAO2, Thousand and one amino acid protein 2, Taok2, Kiaa0881
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Taok2
Synonyms Kiaa0881
Function Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7- mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation (By similarity).
Cellular Location Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Note=Found to be perinuclear and localized to vesicular compartment.
Research Areas
Citations (0)

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Taok2 may play a role in apoptotic morphological changes. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3 and MKK6 kinases. Prevents MAP3K7-mediated activation of IKKA, and thus NF-kappa-B activation. Phosphorylates itself, MBP, activated MAPK8 and tubulins (By similarity).


Blackshaw, S., et al. PLoS Biol. 2 (9), E247 (2004) :Thuret, S., et al. Mol. Cell. Neurosci. 25(3):394-405(2004)Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)Okazaki, N., et al. DNA Res. 10(4):167-180(2003)

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$ 80.00
Cat# BP14470c
(40 western blots)
Availability: In Stock
Bulk Size
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