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TDT Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P04053
Clone Names 80821090
Peptide ID 80821090
Additional Information
Gene ID 1791
Other Names DNA nucleotidylexotransferase, Terminal addition enzyme, Terminal deoxynucleotidyltransferase, Terminal transferase, DNTT, TDT
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TDT {ECO:0000303|PubMed:11473582}
Function Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
Cellular Location Nucleus.
Research Areas
Citations (0)

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This gene is a member of the DNA polymerase type-X familyand encodes a template-independent DNA polymerase that catalyzesthe addition of deoxynucleotides to the 3'-hydroxyl terminus ofoligonucleotide primers. In vivo, the encoded protein is expressedin a restricted population of normal and malignant pre-B and pre-Tlymphocytes during early differentiation, where it generatesantigen receptor diversity by synthesizing non-germ line elements(N-regions) at the junctions of rearranged Ig heavy chain and Tcell receptor gene segments. Alternatively spliced transcriptvariants encoding different isoforms of this gene have beendescribed.


Kubota, T., et al. Genes Cells 12(8):941-959(2007)O'Malley, D.P., et al. Haematologica 91(8):1139-1140(2006)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Thai, T.H., et al. J. Immunol. 173(6):4009-4019(2004)Liu, L., et al. Am. J. Clin. Pathol. 121(6):810-815(2004)

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$ 80.00
Cat# BP14478a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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