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COL1A1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P02452 |
|---|---|
| Clone Names | 100427029 |
| Gene ID | 1277 |
|---|---|
| Other Names | Collagen alpha-1(I) chain, Alpha-1 type I collagen, COL1A1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | COL1A1 |
|---|---|
| Function | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| Cellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793} |
| Tissue Location | Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the pro-alpha1 chains of type I collagenwhose triple helix comprises two alpha1 chains and one alpha2chain. Type I is a fibril-forming collagen found in most connectivetissues and is abundant in bone, cornea, dermis and tendon.Mutations in this gene are associated with osteogenesis imperfectatypes I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlossyndrome Classical type, Caffey Disease and idiopathicosteoporosis. Reciprocal translocations between chromosomes 17 and22, where this gene and the gene for platelet-derived growth factorbeta are located, are associated with a particular type of skintumor called dermatofibrosarcoma protuberans, resulting fromunregulated expression of the growth factor. Two transcripts,resulting from the use of alternate polyadenylation signals, havebeen identified for this gene. [provided by R. Dalgleish].
References
Blades, H.Z., et al. Bone 47(5):989-994(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Jin, H., et al. Osteoporos Int (2010) In press :Szczesny, G., et al. Arch Orthop Trauma Surg (2010) In press :Cheung, M.S., et al. J. Bone Miner. Res. (2010) In press :
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