|Other Names||Sprouty-related, EVH1 domain-containing protein 1, Spred-1, hSpred1, SPRED1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1449d was selected from the N-term region of human SPRED1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein. Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions|
|Tissue Location||Weakly expressed in embryonic cell line HEK293.|
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Provided below are standard protocols that you may find useful for product applications.
SPRED1 is a tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.
Brems,H., Nat. Genet. 39 (9), 1120-1126 (2007)Szafranski,K., Genome Biol. 8 (8), R154 (2007)Yoshida,T., Oncogene 25 (45), 6056-6066 (2006)King,J.A., Biochem. J. 388 (PT 2), 445-454 (2005)
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