|Other Names||Protein phosphatase 1 regulatory subunit 14A, 17 kDa PKC-potentiated inhibitory protein of PP1, Protein kinase C-potentiated inhibitor protein of 17 kDa, CPI-17, PPP1R14A, CPI17, PPP1INL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.|
|Tissue Location||Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.|
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Provided below are standard protocols that you may find useful for product applications.
PPP1R14A is a phosphorylation-dependent inhibitor ofsmooth muscle myosin phosphatase (see MIM 603768). Inhibition leadsto increased myosin phosphorylation and enhances smooth musclecontraction in the absence of increased intracellular Ca(2+)concentration.
Chiba, Y., et al. Biochem. Biophys. Res. Commun. 401(3):487-490(2010)Aslam, M., et al. Cardiovasc. Res. 87(2):375-384(2010)Gudmundsson, J., et al. Nat. Genet. 41(10):1122-1126(2009)Thurneysen, C., et al. Lung Cancer 64(2):140-147(2009)Morin, C., et al. Am. J. Respir. Cell Mol. Biol. 39(6):638-643(2008)
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