|Other Names||Non-homologous end-joining factor 1, Protein cernunnos, XRCC4-like factor, NHEJ1, XLF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17470781). Binds DNA in a length-dependent manner (PubMed:17317666).|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Double-strand breaks in DNA result from genotoxic stressesand are among the most damaging of DNA lesions. This gene encodes aDNA repair factor essential for the nonhomologous end-joiningpathway, which preferentially mediates repair of double-strandedbreaks. Mutations in this gene cause different kinds of severecombined immunodeficiency disorders.
Malivert, L., et al. J. Biol. Chem. 285(34):26475-26483(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)Andres, S.N., et al. Mol. Cell 28(6):1093-1101(2007)Tsai, C.J., et al. Proc. Natl. Acad. Sci. U.S.A. 104(19):7851-7856(2007)
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