|Other Names||Regulatory factor X-associated protein, RFX-associated protein, RFX DNA-binding complex 36 kDa subunit, RFXAP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Part of the RFX complex that binds to the X-box of MHC II promoters.|
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Major histocompatibility (MHC) class II molecules aretransmembrane proteins that have a central role in development andcontrol of the immune system. The protein encoded by this gene,along with regulatory factor X-associated ankyrin-containingprotein and regulatory factor-5, forms a complex that binds to theX box motif of certain MHC class II gene promoters and activatestheir transcription. Once bound to the promoter, this complexassociates with the non-DNA-binding factor MHC class IItransactivator, which controls the cell type specificity andinducibility of MHC class II gene expression. Mutations in thisgene have been linked to bare lymphocyte syndrome type II,complementation group D. Transcript variants utilizing differentpolyA signals have been found for this gene.
Laird, K.M., et al. J. Mol. Biol. 403(1):40-51(2010)Bushway, M., et al. Immunogenetics 62(2):109-116(2010)Briggs, L., et al. Proteins 76(3):655-664(2009)Garvie, C.W., et al. Biochim. Biophys. Acta 1779(12):797-804(2008)van Eggermond, M.C., et al. Mol. Immunol. 45(10):2920-2928(2008)
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