ARFGAP3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NP61 |
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Clone Names | 100525006 |
Gene ID | 26286 |
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Other Names | ADP-ribosylation factor GTPase-activating protein 3, ARF GAP 3, ARFGAP3, ARFGAP1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ARFGAP3 |
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Synonyms | ARFGAP1 |
Function | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. |
Cellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment |
Tissue Location | Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a GTPase-activatingprotein (GAP) that associates with the Golgi apparatus andregulates the early secretory pathway of proteins. The encodedprotein promotes hydrolysis of ADP-ribosylation factor 1(ARF1)-bound GTP, which is required for the dissociation of coatproteins from Golgi-derived membranes and vesicles. Dissociation ofthe coat proteins is a prerequisite for the fusion of thesevesicles with target compartments. The activity of this protein issensitive to phospholipids. Multiple transcript variants encodingdifferent isoforms have been found for this gene. This gene wasoriginally known as ARFGAP1, but that is now the name of a relatedbut different gene.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Saitoh, A., et al. J. Biol. Chem. 284(20):13948-13957(2009)Weimer, C., et al. J. Cell Biol. 183(4):725-735(2008)Frigerio, G., et al. Traffic 8(11):1644-1655(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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