|Other Names||Cytochrome P450 2D6, CYPIID6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CYP2DL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and is known tometabolize as many as 20% of commonly prescribed drugs. Itssubstrates include debrisoquine, an adrenergic-blocking drug;sparteine and propafenone, both anti-arrythmic drugs; andamitryptiline, an anti-depressant. The gene is highly polymorphicin the population; certain alleles result in the poor metabolizerphenotype, characterized by a decreased ability to metabolize theenzyme's substrates. The gene is located near two cytochrome P450pseudogenes on chromosome 22q13.1. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene.
Abduljalil, K., et al. Clin. Pharmacol. Ther. 88(5):643-651(2010)Novalbos, J., et al. J Clin Psychopharmacol 30(5):504-511(2010)Thompson, A.M., et al. Breast Cancer Res. Treat. (2010) In press :Gonzalez-Tejera, G., et al. P R Health Sci J 29(3):299-304(2010)Abraham, J.E., et al. Breast Cancer Res. 12 (4), R64 (2010) :
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