|Other Names||Pulmonary surfactant-associated protein A1, PSP-A, PSPA, SP-A, SP-A1, 35 kDa pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-4, SFTPA1, COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B|
|Function||In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a lung surfactant protein that is amember of a subfamily of C-type lectins called collectins. Theencoded protein binds specific carbohydrate moieties found onlipids and on the surface of microorganisms. This protein plays anessential role in surfactant homeostasis and in the defense againstrespiratory pathogens. Mutations in this gene are associated withidiopathic pulmonary fibrosis. Alternate splicing results inmultiple transcript variants.
Silveyra, P., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 299 (4), L523-L534 (2010) :Liu, D.Y., et al. Zhongguo Dang Dai Er Ke Za Zhi 12(6):444-446(2010)Liu, J., et al. Tohoku J. Exp. Med. 221(1):35-42(2010)Berg, T., et al. Biochim. Biophys. Acta 1543(1):159-173(2000)Childs, R.A., et al. J. Biol. Chem. 267(14):9972-9979(1992)
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