|Other Names||Wiskott-Aldrich syndrome protein family member 2, WASP family protein member 2, Protein WAVE-2, Verprolin homology domain-containing protein 2, WASF2, WAVE2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=At the interface between the lamellipodial actin meshwork and the membrane|
|Tissue Location||Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.|
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This gene encodes a member of the Wiskott-Aldrich syndromeprotein family. The gene product is a protein that forms amultiprotein complex that links receptor kinases and actin. Bindingto actin occurs through a C-terminal verprolin homology domain inall family members. The multiprotein complex serves to tranducesignals that involve changes in cell shape, motility or function.The published map location (PMID:10381382) has been changed basedon recent genomic sequence comparisons, which indicate that theexpressed gene is located on chromosome 1, and a pseudogene may belocated on chromosome X.
Takahashi, K., et al. Cell. Signal. 22(3):510-518(2010)Lebensohn, A.M., et al. Mol. Cell 36(3):512-524(2009)Cai, X., et al. Lung Cancer 65(3):299-305(2009)Morimura, S., et al. Biochem. Biophys. Res. Commun. 382(3):614-619(2009)Takahashi, K., et al. Cell. Signal. 21(5):695-703(2009)
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