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KCNC1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P48547
Clone Names 100507078
Peptide ID 100507078
Additional Information
Gene ID 3746
Other Names Potassium voltage-gated channel subfamily C member 1, NGK2, Voltage-gated potassium channel subunit Kv31, Voltage-gated potassium channel subunit Kv4, KCNC1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNC1
Function Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:25401298). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
Cellular Location Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Background

The Shaker gene family of Drosophila encodes components ofvoltage-gated potassium channels and is comprised of foursubfamilies. Based on sequence similarity, this gene is similar toone of these subfamilies, namely the Shaw subfamily. The proteinencoded by this gene belongs to the delayed rectifier class ofchannel proteins and is an integral membrane protein that mediatesthe voltage-dependent potassium ion permeability of excitablemembranes. Multiple transcript variants encoding different isoformshave been inferred for this gene based on orthologous loci.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Wang, Z., et al. J. Gen. Physiol. 133(4):361-374(2009)Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)Devaux, J., et al. J. Neurosci. 23(11):4509-4518(2003)

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$ 80.00
Cat# BP14545b
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