|Other Names||Suppressor of cytokine signaling 4, SOCS-4, Suppressor of cytokine signaling 7, SOCS-7, SOCS4, SOCS7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains a SH2 domain anda SOCS BOX domain. The protein thus belongs to the suppressor ofcytokine signaling (SOCS), also known as STAT-induced STATinhibitor (SSI), protein family. SOCS family members are known tobe cytokine-inducible negative regulators of cytokine signaling.Two alternatively spliced transcript variants encoding the sameprotein have been found for this gene.
Hu, G., et al. J. Infect. Dis. 202(1):125-135(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Sasi, W., et al. BMC Cancer 10, 178 (2010) :Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009)
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