|Other Names||Iroquois-class homeodomain protein IRX-3, Homeodomain protein IRXB1, Iroquois homeobox protein 3, IRX3, IRXB1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
IRX3 is a member of the Iroquois homeobox gene family (seeIRX1; MIM 606197) and plays a role in an early step of neuraldevelopment (Bellefroid et al., 1998 [PubMed 9427753]). Members ofthis family appear to play multiple roles during pattern formationof vertebrate embryos (Lewis et al., 1999 [PubMed10370142]).
Ragvin, A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(2):775-780(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)Lewis, M.T., et al. Cell Tissue Res. 296(3):549-554(1999)Bellefroid, E.J., et al. EMBO J. 17(1):191-203(1998)
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