|Other Names||UV excision repair protein RAD23 homolog A, HR23A, hHR23A, RAD23A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in vpr-dependent replication of HIV-1 in non- proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.|
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The protein encoded by this gene is one of two humanhomologs of Saccharomyces cerevisiae Rad23, a protein involved innucleotide excision repair (NER). This protein was shown tointeract with, and elevate the nucleotide excision activity of3-methyladenine-DNA glycosylase (MPG), which suggested a role inDNA damage recognition in base excision repair. This proteincontains an N-terminal ubiquitin-like domain, which was reported tointeract with 26S proteasome, as well as with ubiquitin proteinligase E6AP, and thus suggests that this protein may be involved inthe ubiquitin mediated proteolytic pathway in cells. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :Li, G., et al. PLoS ONE 5 (6), E11371 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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