|Other Names||Kallikrein-10, 3421-, Normal epithelial cell-specific 1, Protease serine-like 1, KLK10, NES1, PRSSL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has a tumor-suppressor role for NES1 in breast and prostate cancer.|
|Tissue Location||Expressed in breast, ovary and prostate.|
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Kallikreins are a subgroup of serine proteases havingdiverse physiological functions. Growing evidence suggests thatmany kallikreins are implicated in carcinogenesis and some havepotential as novel cancer and other disease biomarkers. This geneis one of the fifteen kallikrein subfamily members located in acluster on chromosome 19. Its encoded protein is secreted and mayplay a role in suppression of tumorigenesis in breast and prostatecancers. Alternate splicing of this gene results in multipletranscript variants encoding the same protein. [provided byRefSeq].
Batra, J., et al. Int. J. Gynecol. Cancer 20(4):529-536(2010)Klein, R.J., et al. Cancer Prev Res (Phila) 3(5):611-619(2010)Papageorgis, P., et al. Cancer Res. 70(3):968-978(2010)Lu, C.Y., et al. Genes Chromosomes Cancer 48(12):1057-1068(2009)Sardana, G., et al. Clin. Biochem. 42 (13-14), 1483-1486 (2009) :
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