|Other Names||Histone acetyltransferase type B catalytic subunit, Histone acetyltransferase 1, HAT1, KAT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.|
|Cellular Location||Isoform A: Nucleus matrix.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a type B histoneacetyltransferase (HAT) that is involved in the rapid acetylationof newly synthesized cytoplasmic histones, which are in turnimported into the nucleus for de novo deposition onto nascent DNAchains. Histone acetylation, particularly of histone H4, plays animportant role in replication-dependent chromatin assembly.Specifically, this HAT can acetylate soluble but not nucleosomalhistone H4 at lysines 5 and 12, and to a lesser degree, histone H2Aat lysine 5. Alternatively spliced transcript variants have beenidentified for this gene.
Saade, E., et al. Proteomics 9(21):4934-4943(2009)Miyamoto, N., et al. J. Biol. Chem. 283(26):18218-18226(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Benson, L.J., et al. J. Biol. Chem. 282(2):836-842(2007)
If you have any additional inquiries please email technical services at email@example.com.