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PSMB8 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P28062
Clone Names 100507200
Peptide ID 100507200
Additional Information
Gene ID 5696
Other Names Proteasome subunit beta type-8, Low molecular mass protein 7, Macropain subunit C13, Multicatalytic endopeptidase complex subunit C13, Proteasome component C13, Proteasome subunit beta-5i, Really interesting new gene 10 protein, PSMB8, LMP7, PSMB5i, RING10, Y2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSMB8
Synonyms LMP7, PSMB5i, RING10, Y2
Function The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.
Cellular Location Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00809}. Nucleus
Research Areas
Citations (0)

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The proteasome is a multicatalytic proteinase complex witha highly ordered ring-shaped 20S core structure. The core structureis composed of 4 rings of 28 non-identical subunits; 2 rings arecomposed of 7 alpha subunits and 2 rings are composed of 7 betasubunits. Proteasomes are distributed throughout eukaryotic cellsat a high concentration and cleave peptides in anATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome,is the processing of class I MHC peptides. This gene encodes amember of the proteasome B-type family, also known as the T1Bfamily, that is a 20S core beta subunit. This gene is located inthe class II region of the MHC (major histocompatibility complex).Expression of this gene is induced by gamma interferon and thisgene product replaces catalytic subunit 3 (proteasome beta 5subunit) in the immunoproteasome. Proteolytic processing isrequired to generate a mature subunit. Two alternative transcriptsencoding two isoforms have been identified; both isoforms areprocessed to yield the same mature subunit.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Bravo, M.J., et al. Hum. Immunol. 71(7):708-711(2010)Shi, C., et al. Epidemiol. Infect., 1-9 (2010) In press :Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Ustrell, V., et al. FEBS Lett. 376(3):155-158(1995)

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$ 80.00
Cat# BP14577a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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