|Other Names||Placenta growth factor, PlGF, PGF, PGFL, PLGF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.|
|Cellular Location||Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin|
|Tissue Location||While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas|
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Provided below are standard protocols that you may find useful for product applications.
The PGF gene encodes placenta growth factor, a homolog ofvascular endothelial growth factor (VEGFA; MIM 192240), thatselectively binds to VEGFR1 (FLT1; MIM 165070) and is involved inangiogenesis (Fischer et al., 2007 [PubMed 17981115]; Bais et al.,2010 [PubMed 20371352]).
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Cowans, N.J., et al. Prenat. Diagn. 30(6):565-570(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :Andersson, M.K., et al. BMC Cancer 10, 249 (2010) :Pan, P., et al. BMC Cell Biol. 11, 36 (2010) :
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